Key Publications

(* denotes authors contributed equally) 

1.   Fazal FM*, Han S*, Parker KR, Kaewsapsak P, Xu J, Boettiger AN, Chang HY, Ting AY. Atlas of Subcellular RNA Localization Revealed by APEX-seq. Cell, 178, 473–490 (2019). doi.org/10.1016/j.cell.2019.05.027 [PDF and Protocol] [Covered by GenomeWeb, Nature Technology Feature, Preprint Highlights and F1000Prime Recommended] [bioRxiv]

2.   Sun L*, Fazal FM*, Li P*, Broughton JP, Lee B, Tang L, Huang W, Kool ET, Chang HY, Zhang QC. RNA structure maps across mammalian cellular compartments. Nature Structural and Molecular Biology (NSMB), 26, 322-330 (2019). doi.org/10.1038/s41594-019-0200-7 [PDF] [NSMB News and Views and Tsinghua Coverage] [bioRxiv]

3.   Meng CA*, Fazal FM*, Block SM. Real-time observation of polymerase-promoter contact remodeling during transcription initiation. Nature Communications, 8(1), 1178 (2017). doi:10.1038/s41467-017-01041-1 [PDF]

4.   Fazal FM*, Meng CA*, Murakami K*, Kornberg RD, Block SM. Real-time observation of the initiation of RNA polymerase II transcription. Nature, 525(7568), 274-277 (2015). doi:10.1038/nature14882 [PDF] [Covered by Stanford News, Biotechniques, Phys.org and Yeast Genome Database

5.   Fazal FM*, Koslover DJ*, Luisi BF, Block SM. Direct observation of processive exoribonuclease motion using optical tweezers. Proceedings of the National Academy of Sciences (PNAS), 112(49), 15101-15106 (2015). doi:10.1073/pnas.1514028112 [PDF]

Other Publications

6.   Fazal FM, Chang HY. LncRNA structure: message to the heart. Molecular Cell, 64(1), 1-2 (2016). doi:10.1016/j.molcel.2016.09.030 [PDF]

7.   Koslover DJ*, Fazal FM*, Mooney RA, Landick R, Block SM. Binding and translocation of termination factor Rho studied at the single-molecule level. Journal of Molecular Biology (JMB), 423(5), 664-676 (2012). doi:10.1016/j.jmb.2012.07.027 [PDF] [JMB Commentary, Featured Article and Cover]

8.   Fazal FM, Block SM. Optical tweezers study life under tension. Nature Photonics, 5(6), 318-321 (2011). doi:10.1038/nphoton.2011.100 [PDF] [Nobel Prize in Physics 2018 Nature Collection]

9.   Fazal FM, Sridharan TK, Qui K, Whitney B, Zhang Q, Robitaille T. Spectral energy distributions of high-mass protostellar objects – evidence for high accretion rates. Astrophysical Journal Letters (ApJL), 688, L41-L44 (2008). doi:10.1086/593975 [PDF]

10.   Fazal FM, Hansen DE. Glucose-specific poly(allylamine) hydrogels – a reassessment. Bioorganic and Medicinal Chemistry Letters (BMCL), 17(1), 235-238 (2007). doi:10.1016/j.bmcl.2006.09.054 [PDF]

11.   Ghosh A, Fazal FM, Fischer P. Circular differential double diffraction in chiral media. Optics Letters, 32(13), 1836-1838 (2007). doi:10.1364/OL.32.001836 [PDF]

Submitted

12. Maas-Bauer K, Simonetta F, Hirai T, Lohmeyer JK, Fazal FM, Litzenburger UM, Yost KE, Ribado JV, Kambham N, Wenokur AS, Alvarez M, Mavers M, Baker J, Bhatt AS, Chang HY, Negrin RS. Invariant natural killer T (iNKT) cell subsets differentially mediate cytotoxic and immune regulatory functions. [Abstract]