Key Publications

(* denotes authors contributed equally) 

1.   Fazal FM*, Han S*, Parker KR, Kaewsapsak P, Xu J, Boettiger AN, Chang HY, Ting AY. Atlas of Subcellular RNA Localization Revealed by APEX-seq. Cell, 178, 473–490 (2019). doi.org/10.1016/j.cell.2019.05.027 [PDF and Protocol] [Covered by GenomeWeb] [bioRxiv, Preprint Highlights and F1000Prime Recommended]

2.   Sun L*, Fazal FM*, Li P*, Broughton JP, Lee B, Tang L, Huang W, Kool ET, Chang HY, Zhang QC. RNA structure maps across mammalian cellular compartments. Nature Structural and Molecular Biology (NSMB), 26, 322-330 (2019). doi.org/10.1038/s41594-019-0200-7 [PDF] [NSMB News and Views and Tsinghua Coverage] [bioRxiv]

3.   Meng CA*, Fazal FM*, Block SM. Real-time observation of polymerase-promoter contact remodeling during transcription initiation. Nature Communications, 8(1), 1178 (2017). doi:10.1038/s41467-017-01041-1 [PDF]

4.   Fazal FM*, Meng CA*, Murakami K*, Kornberg RD, Block SM. Real-time observation of the initiation of RNA polymerase II transcription. Nature, 525(7568), 274-277 (2015). doi:10.1038/nature14882 [PDF] [Covered by Stanford News, Biotechniques, Phys.org and Yeast Genome Database

5.   Fazal FM*, Koslover DJ*, Luisi BF, Block SM. Direct observation of processive exoribonuclease motion using optical tweezers. Proceedings of the National Academy of Sciences (PNAS), 112(49), 15101-15106 (2015). doi:10.1073/pnas.1514028112 [PDF]

Other Publications

6.   Fazal FM, Chang HY. LncRNA structure: message to the heart. Molecular Cell, 64(1), 1-2 (2016). doi:10.1016/j.molcel.2016.09.030 [PDF]

7.   Koslover DJ*, Fazal FM*, Mooney RA, Landick R, Block SM. Binding and translocation of termination factor Rho studied at the single-molecule level. Journal of Molecular Biology (JMB), 423(5), 664-676 (2012). doi:10.1016/j.jmb.2012.07.027 [PDF] [JMB Commentary, Featured Article and Cover]

8.   Fazal FM, Block SM. Optical tweezers study life under tension. Nature Photonics, 5(6), 318-321 (2011). doi:10.1038/nphoton.2011.100 [PDF] [Nobel Prize in Physics 2018 Nature Collection]

9.   Fazal FM, Sridharan TK, Qui K, Whitney B, Zhang Q, Robitaille T. Spectral energy distributions of high-mass protostellar objects – evidence for high accretion rates. Astrophysical Journal Letters (ApJL), 688, L41-L44 (2008). doi:10.1086/593975 [PDF]

10.   Fazal FM, Hansen DE. Glucose-specific poly(allylamine) hydrogels – a reassessment. Bioorganic and Medicinal Chemistry Letters (BMCL), 17(1), 235-238 (2007). doi:10.1016/j.bmcl.2006.09.054 [PDF]

11.   Ghosh A, Fazal FM, Fischer P. Circular differential double diffraction in chiral media. Optics Letters, 32(13), 1836-1838 (2007). doi:10.1364/OL.32.001836 [PDF]